Clinical Applications Based Questions in Physiology presents case based questions on most of the topics in physiology, arranged in a system-wise manner, following the CBME Guidelines | Competency Based Undergraduate Curriculum for the Indian Medical Graduate. Questions are arranged sequentially so as they build upon each other. The difficulty of questions varies from the simple to progressing into the applied, problem-solving ones. This order will kindle the thought processes of students and enhance their ability to apply knowledge of physiology concepts to clinical medicine. By solving the case-based questions, they will be equipped with the skills of self-directed learning and this integration of basic and clinical sciences will help them understand clearly the big picture of disease process.