Genetically transmitted Sickle Cell Haemoglobinopathy is caused by a flaw in the beta chain of haemoglobin where glutamic acid at position six is changed to valine. The aetiopathogenesis of the illness has been uncovered by extensive research, which has also made precise laboratory diagnosis possible. In the scheduled tribes and scheduled castes of Central India, sickle cell hemoglobinopathy is very common. The result of two and a half decades of intensive investigation is this monogram. It covers the anthropological measures, radiological features, historical aspects, and etiopathogenesis of the disease before going into great depth regarding how each person's skeleton is affected by sickle cell anaemia. This book will help orthopaedic surgeons, doctors, paediatricians, and radiologists identify patients, comprehend the illness process, and handle cases effectively. the key aim of the monogram is to present a precise and concise description of all aspects of the orthopaedic manifestations of the disease that will be of help to medical professionals to offer the patients of Sickle Cell Haemoglobinopathy a better prognosis.