This textbook contains essential information that readers need to prepare for lectures, classroom activities, examinations, clinical assignments and effective nursing care for patients. Its primary objective is to provide knowledge about disease conditions and management for them. This book emphasizes on structure, physiological, pathophysiological, psychological and social concepts related to diseases and nursing care. This books contains not only theory but also practical part also. Apart from this textbook also contains material for self assessment and competitive examinations. This textbook is written in a very simple language which is easily understandable. This book covers all major and almost all minor diseases of body systems. This book fulfills all the requirements of Undergraduate (UG), Postgraduate (PG), Educator, Researcher and Paramedical Professionals. SALIENT FEATURES OF THE BOOK ARE: This book contains 12 units, each providing a description of a major body system and the diseases and disorders which can affect that system. A brief review of anatomy and physiology, focusing on information that will promote understanding of nursing care. Disease conditions cover DEFINITION, TYPES, STAGES (in cancers), ETIOLOGY, RISK FACTORS, PATHOPHYSIOLOGY, CLINICAL MANIFESTATIONS, DIAGNOSTIC EVALUATION, MANAGEMENT (Medical, Surgical, Nursing and Dietary Management), HEALTH EDUCATION, PREVENTION AND COMPLICATIONS. Special and alternative therapies are mentioned for each system. Diagnostic, Therapeutic and Nursing procedures are explained at the end of each chapter. Suitable figures and tables are available for better understanding of topic. Lists of drugs are prepared for better understanding their action and importance in treatment of disease conditions. At the end of each chapter, relevant short questions and long questions along with multiple choice questions with answer keys are added to help the readers in preparing for the examination. Detailed explanation of