This textbook is designed for undergraduate and postgraduate students of engineering, computer science, computer application and information technology. This book covers the wide range of topics in very lucid manner for better understanding of the students. Along with the basic topics of Python programming this book also covers in-built data structures of Python, File handling, classes and Objects, Inheritance, Operator Overloading, Exception handling. Some advanced features like Numpy, Pandas, Matplotlib, Multithreaded Programming are also discussed in this book. Various programming examples along with new problems for practice and a set of MCQ questions at the end of each chapter are included for increasing self learning process of the students