This book, which was specifically developed with experimental biologists in mind, provides as an introduction to the wide range of computational approaches to gene regulation modelling and analysis. Intuitive explanations are provided, and mathematical jargon is avoided. If equations must be used, they are derived from basic principles or, at the very least, an understandable explanation is given. For use in activities in the classroom and in self-guided learning, there are a lot of examples and model descriptions offered. For this reason, the book is perfect for self-study as well as serving as the foundation for a semester-long course for undergraduate and graduate students studying molecular biology, bioengineering, genomic sciences, or systems biology.