This book is a one-stop solution for pulmonologists, intensivists, anesthetists, respiratory therapists, nurses working in ICUs and all physicians dealing with patients on mechanical ventilators. Earlier editions were authored by a pulmonologist and a respiratory therapist. The new third edition (2024) has been authored by 55 top class multinational authors. These 55 authors were handpicked from four specialties: Pulmonology, critical care, anesthesia and respiratory care. Nine new chapters were added, and almost all the previous chapters were rewritten infusing latest published data. The chapters are refreshingly readable as all the authors are actively practicing and also many of them publishing articles, writing reviews. The fact that all of them are actively practicing the care of patients being treated on mechanical ventilators. The 534 pages with 35 chapters are packed with practical information, exactly what a young clinician is looking for. This book is worth reading, keeping on your study table, referring daily in the ICUs, and of course, this book makes an ideal gift to young doctors and respiratory therapists after their postgraduation.