The complete syllabus has been thoroughly rewritten and updated in accordance with the requirements of the competency-based medical education (CBME) curriculum. Each chapter's introduction lists the chapter's competencies. The student must possess a good understanding of these subjects. To make it simpler for the student to read, remember, and replicate, new concepts have been added and simplified. Study guides are offered at the conclusion of each system. MCQs are included for self-evaluation. At the conclusion of each system and throughout the chapters, clinical case studies are added. several new, pertinent tables and figures have been added. The information on the most recent COVID-19 disease is also supplied. Reading for last-minute preparation includes essential spoken questions and their answers for a quick review of each system. also helpful for short and brief answer questions.