Fan favourites Jack and Laurie are drawn into the murky depths of hospital perils when a doctor is murdered in Robin Cook's thrilling medical mystery-thriller Night Shift. The married doctors Jack Stapleton and Laurie Montgomery both practise medicine in the bustling city of New York. The last thing they need is a murder on their plate as they try to juggle their busy schedules and family obligations. However, an autopsy is necessary when Laurie's longtime friend Dr. Sue Passero unexpectedly passes away in a hospital parking garage, which is directly under Laurie's purview as the recently appointed chief medical examiner. Therefore, Jack finds it difficult to decline Laurie's request to do the examination with extra care.