The fifth edition of the Textbook of Biochemistry incorporates significant revisions that emphasize the clinical orientation and integration aspects of the CBME syllabus. It thus includes a larger number of case studies throughout the text for providing students with early clinical exposure, as well as vertical and horizontal integration boxes that show the relationship between biochemistry and other medical subjects. The revisions also ensure that the CBME syllabus is complied with in all respects and the book continues to provide undergraduate medical students with an easy-to-understand overview of biochemistry concepts. The book will also be a valuable study resource for students of allied health fields and those preparing for competitive examinations.