This book aims to serve as a complete textbook for the students of B. Pharm Eight semester. This book explains the fundamentals of Computer Aided Drug Design (CADD) and methods that are heavily dependent on bioinformatics tools, application and information technology, information management, software applications, databases and computational resources all provide the infrastructure for bioinformatics and biotechnology. Computer Aided Drug Design is central to rational drug design and drug discovery process. There are several key areas where bioinformatics supports Computer Aided Drug Discovery Designing research.