We are pleased to announce the release of "Principles of Pharmacology," third edition, which builds on the strengths of the first two editions and incorporates, in particular, the painstakingly accumulated most recent pharmacological updates. The past several years have seen a rise in its popularity among both students and professors, confirming its status as a cornerstone of pharmacology. Text not only informs, but it also enlightens the mind on the best pharmaceuticals to choose for patient care strategy's component of drug evaluation and monitoring. It is presented in a clear, simple, and exact manner with understandable concepts and covers a broad range of subjects supported by drug trials. The emphasis of the textbook is on making learning simple to understand.It provides a comprehensive overview of the most recent medications and therapy techniques while reflecting reliable data on how medicines work and how they interact with various disorders. With current advances, all chapters have undergone extensive revisions. The book concentrates on fundamental and elaborated information that are simple for readers to understand and retain, and it has many well organised and unambiguous images. The book encourages readers to study the principles of pharmacology for rational drug therapy, preserving the ideals of rational pharmacotherapeutics for future generations. Its reading not only aids in achieving high marks but also inspires students to pursue careers in pharmacology, creating new opportunities in the healthcare industry.