The Endless are a dysfunctional family of cosmic beings who have ruled over the realms of dream, desire, despair, destiny, destruction, death, and delirium since the beginning of time. They are older and more powerful than the gods themselves. However, three hundred years ago, one of the mythical beings abandoned his responsibilities and left his realm, never to be seen again. Delirium and Dream, now on a mission to find their missing sibling, encounter immortal humans and various deities as they search for the prodigal Destruction. However, as their journey leads Dream to a final, tragic confrontation with his son Orpheus, the eternal being discovers the true meaning of fate and consequences. This volume collects The Sandman #41-49.